Organoids as a novel tool in modelling infectious diseases.
Semin Cell Dev Biol
; 144: 87-96, 2023 07 30.
Article
de En
| MEDLINE
| ID: mdl-36182613
ABSTRACT
Infectious diseases worldwide affect human health and have important societal impacts. A better understanding of infectious diseases is urgently needed. In vitro and in vivo infection models have brought notable contributions to the current knowledge of these diseases. Organoids are multicellular culture systems resembling tissue architecture and function, recapitulating many characteristics of human disease and elucidating mechanisms of host-infectious agent interactions in the respiratory and gastrointestinal systems, the central nervous system and the skin. Here, we discuss the applicability of the organoid technology for modeling pathogenesis, host response and features, which can be explored for the development of preventive and therapeutic treatments.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Organoïdes
/
Maladies transmissibles
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Semin Cell Dev Biol
Sujet du journal:
EMBRIOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Brésil