Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer.

Mudd, Gemma E; Scott, Heather; Chen, Liuhong; van Rietschoten, Katerine; Ivanova-Berndt, Gabriela; Dzionek, Katarzyna; Brown, Amy; Watcham, Sophie; White, Lewi; Park, Peter U; Jeffrey, Phil; Rigby, Mike; Beswick, Paul

Mudd, Gemma E; Scott, Heather; Chen, Liuhong; van Rietschoten, Katerine; Ivanova-Berndt, Gabriela; Dzionek, Katarzyna; Brown, Amy; Watcham, Sophie; White, Lewi; Park, Peter U; Jeffrey, Phil; Rigby, Mike; Beswick, Paul.

Affiliation

Mudd GE; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Scott H; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Chen L; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
van Rietschoten K; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Ivanova-Berndt G; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Dzionek K; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Brown A; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Watcham S; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
White L; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Park PU; Bicycle Therapeutics, Inc., 4 Hartwell Place, Lexington 02421-3122, Massachusetts, United States.
Jeffrey P; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Rigby M; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.
Beswick P; BicycleTx Limited, B900 Babraham Research Campus, Cambridge CB22 3AT, U.K.

J Med Chem ; 65(21): 14337-14347, 2022 11 10.

Article de En | MEDLINE | ID: mdl-36204777

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunotoxines / Immunoconjugués / Tumeurs / Antinéoplasiques Limites: Humans Langue: En Journal: J Med Chem Sujet du journal: QUIMICA Année: 2022 Type de document: Article Pays d'affiliation: Royaume-Uni Pays de publication: États-Unis d'Amérique

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