Adenoid cystic carcinoma of the head and neck: Patterns of recurrence and implications for intensity-modulated radiotherapy.
Head Neck
; 45(1): 187-196, 2023 Jan.
Article
de En
| MEDLINE
| ID: mdl-36222355
ABSTRACT
BACKGROUND:
We seek to inform radiotherapy (RT) delivery for adenoid cystic carcinoma of the head and neck (ACC) by evaluating RT techniques and recurrence patterns.METHODS:
We identified patients with ACC treated with curative-intent RT from 2005 to 2021. Imaging was reviewed to determine local recurrence (LR).RESULTS:
Ninety-one patients were included. The 5-year LR risk was 12.2% (6.6-22.7). One patient each experienced a marginal and out-of-field recurrence. Patients receiving >60 Gy postoperatively had a 5-year LR risk of 0% compared to 10.7% (4.2-27.2) with ≤60 Gy. Those receiving 70 and <70 Gy definitively had a 5-year LR risk of 15.2% (2.5-91.6) and 33.3% (6.7-100.0), respectively. No patients had regional nodal failure.CONCLUSIONS:
Modern, conformal RT for ACC results in low rates of LR. Doses >60 and 70 Gy may improve control in the postoperative and definitive settings, respectively. Elective nodal treatment can be omitted in well-selected patients.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Carcinome adénoïde kystique
/
Radiothérapie conformationnelle
/
Radiothérapie conformationnelle avec modulation d'intensité
/
Tumeurs de la tête et du cou
Limites:
Humans
Langue:
En
Journal:
Head Neck
Sujet du journal:
NEOPLASIAS
Année:
2023
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique