Manipulation of Redox Metabolism Using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-Sensitization by ATM Inhibitors in Colorectal Cancer.

Callaghan, Cameron M; Abukhiran, Ibrahim M; Masaadeh, Amr; Van Rheeden, Richard V; Kalen, Amanda L; Rodman, Samuel N; Petronek, Michael S; Mapuskar, Kranti A; George, Benjamin N; Coleman, Mitchell C; Goswami, Prabhat C; Allen, Bryan G; Spitz, Douglas R; Caster, Joseph M

Callaghan, Cameron M; Abukhiran, Ibrahim M; Masaadeh, Amr; Van Rheeden, Richard V; Kalen, Amanda L; Rodman, Samuel N; Petronek, Michael S; Mapuskar, Kranti A; George, Benjamin N; Coleman, Mitchell C; Goswami, Prabhat C; Allen, Bryan G; Spitz, Douglas R; Caster, Joseph M.

Affiliation

Callaghan CM; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Abukhiran IM; Department of Pathology, University of Iowa Hospitals and Clinics and Carver College of Medicine, Iowa City, Iowa.
Masaadeh A; Department of Pathology, University of Iowa Hospitals and Clinics and Carver College of Medicine, Iowa City, Iowa.
Van Rheeden RV; Department of Pediatrics, The University of Iowa, Iowa City, Iowa.
Kalen AL; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Rodman SN; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Petronek MS; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Mapuskar KA; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
George BN; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa.
Coleman MC; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Goswami PC; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Allen BG; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Spitz DR; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa.
Caster JM; Department of Radiation Oncology, University of Iowa Hospital and Clinics, Iowa City, Iowa; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa. Electronic address: joseph-caster@uiowa.edu.

Int J Radiat Oncol Biol Phys ; 115(4): 933-944, 2023 03 15.

Article de En | MEDLINE | ID: mdl-36228747

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du pancréas / Ataxie-télangiectasie Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: Int J Radiat Oncol Biol Phys Année: 2023 Type de document: Article

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