Surveillance of SARS-CoV-2 Antibodies in Early 2020 among Rhode Island Pregnancies.
Ann Clin Lab Sci
; 52(5): 788-795, 2022 Sep.
Article
de En
| MEDLINE
| ID: mdl-36261192
ABSTRACT
OBJECTIVE:
Limited data are available on the performance of SARS-CoV-2 antibody assays and data collected during pregnancy vary widely. The objective of this study was to estimate the seroprevalence of antibodies against SARS-CoV-2 in pregnant individuals in Rhode Island and to evaluate whether the prevalence differed by month of collection, age, county of residence, or economic status as estimated by zip code.METHODS:
Pre-pandemic (2019) and early pandemic (2020) serum samples, collected for prenatal screening between 15 and 22 weeks of gestation, were analyzed utilizing two SARS-CoV-2 immunoglobulin G (IgG) automated assays that targeted the viral nucleocapsid (anti-N) or spike (anti-S) receptor binding domain proteins.RESULTS:
Among 756 pre-pandemic samples, one anti-S IgG and 13 anti-N IgG were identified. No samples were positive for both. Among 787 pandemic specimens, 16 (2.03%) were positive for both anti-N IgG and anti-S IgG. When stratified by month of collection, there was a significant increase in seropositivity rate (p=0.023). Seropositivity rates were associated with lower income levels (p=0.08) but this was not statistically significant. No trend by maternal age was found (p=0.70).CONCLUSIONS:
When a positive result was defined as both anti-N IgG and anti-S IgG, false positives were unlikely. Based on this methodology, serology could be utilized to monitor infection trends during pregnancy.Mots clés
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
SARS-CoV-2
/
COVID-19
Type d'étude:
Risk_factors_studies
/
Screening_studies
Limites:
Female
/
Humans
/
Pregnancy
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
Ann Clin Lab Sci
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique