SHP-1 knockdown suppresses mitochondrial biogenesis and aggravates mitochondria-dependent apoptosis induced by all trans retinal through the STING/AMPK pathways.

Zhuang, Xiaonan; Ma, Jun; Xu, Gezhi; Sun, Zhongcui

Zhuang, Xiaonan; Ma, Jun; Xu, Gezhi; Sun, Zhongcui.

Affiliation

Zhuang X; Department of Ophthalmology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Ma J; Shanghai Key Laboratory of Visual Impairment and Restoration, Fudan University, Shanghai, China.
Xu G; NHC Key Laboratory of Myopia, Fudan University, Shanghai, China.
Sun Z; Eye Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.

Mol Med ; 28(1): 125, 2022 10 22.

Article de En | MEDLINE | ID: mdl-36273174

Sujet(s)
Mots clés

Adenosine monophosphate-activated protein kinase; Age-related macular degeneration; All trans retinal; Mitochondrial biogenesis; Retinal pigment epithelium; Src-homology 2 domain-containing phosphatase-1; Stimulator of interferon genes

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Rétinal / Épithélium pigmentaire de la rétine / Dégénérescence maculaire / Mitochondries Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Mol Med Sujet du journal: BIOLOGIA MOLECULAR Année: 2022 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni

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