Pharmacological treatment strategies of pterygium: Drugs, biologics, and novel natural products.
Drug Discov Today
; 28(1): 103416, 2023 01.
Article
de En
| MEDLINE
| ID: mdl-36280041
ABSTRACT
Pterygium is a fibrovascular tissue growth invading the cornea. Adjunctive treatment post-surgery includes conventional immunosuppressants as well as antiviral drugs. The use of large- and small-molecule antivascular endothelial growth factor (VEGF) agents remains an integral part of pterygium treatment as well as other neovascular conditions of the eye. Naturally occurring polyphenolic compounds have favorable characteristics for treating neovascular and inflammatory eye conditions, including good efficacy, stability, cost-effectiveness, and the versatility of their chemical synthesis. In this review, we discuss pharmacological treatments of pterygium. Natural products, such curcumin, ellagic acid, and chalcones, are reviewed, with emphasis on their potential as future pterygium treatments.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Produits biologiques
/
Ptérygion
Limites:
Humans
Langue:
En
Journal:
Drug Discov Today
Sujet du journal:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Année:
2023
Type de document:
Article
Pays d'affiliation:
Royaume-Uni