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A cryptic transactivation domain of EZH2 binds AR and AR's splice variant, promoting oncogene activation and tumorous transformation.
Wang, Jun; Park, Kwang-Su; Yu, Xufen; Gong, Weida; Earp, H Shelton; Wang, Gang Greg; Jin, Jian; Cai, Ling.
Affiliation
  • Wang J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
  • Park KS; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
  • Yu X; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Gong W; Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences and Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
  • Earp HS; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
  • Wang GG; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
  • Jin J; Department of Pharmacology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
  • Cai L; Department of Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, 27599, USA.
Nucleic Acids Res ; 50(19): 10929-10946, 2022 10 28.
Article de En | MEDLINE | ID: mdl-36300627
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteurs aux androgènes / Tumeurs prostatiques résistantes à la castration / Protéine-2 homologue de l'activateur de Zeste Limites: Humans / Male Langue: En Journal: Nucleic Acids Res Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Récepteurs aux androgènes / Tumeurs prostatiques résistantes à la castration / Protéine-2 homologue de l'activateur de Zeste Limites: Humans / Male Langue: En Journal: Nucleic Acids Res Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique