The comparative effects of erythromycin and amikacin on acute respiratory Pseudomonas aeruginosa infection.
Vet Med Sci
; 9(2): 867-875, 2023 03.
Article
de En
| MEDLINE
| ID: mdl-36318447
ABSTRACT
BACKGROUND:
One of the most common causes of pneumonia is Pseudomonas aeruginosa (P. aeruginosa). As with other microbial pathogens, this bacterium tends to develop resistance to various antibiotics. Amikacin and erythromycin, which are from the aminoglycoside and macrolide antibiotic families, are used to treat respiratory infections caused by P. aeruginosa.OBJECTIVES:
This study explored whether amikacin, erythromycin or a combination of both works better against P. aeruginosa acute lung infection.METHODS:
For this study, 32 rats were used. The trachea of rats was exposed aseptically and their lung was infected with P. aeruginosa through trachea. Then, according to the group, they received amikacin, erythromycin or a combination of both for 1 week. Finally, they were euthanised on the 3rd and 7th days post-infection. The macroscopic and microscopic evaluations of the lungs, kidney and liver were performed. The right lung was collected for in vivo bacteriological analysis.RESULTS:
The amikacin group (A group) had a statistically significantly lower macroscopic and microscopic scores than the other groups (p < 0.05). In vivo bacteriological test revealed that the A group had significantly lower lung bacterial load (p < 0.05).CONCLUSIONS:
In summary, it was concluded that amikacin could help alleviate the respiratory infection caused by P. aeruginosa solely, and it was more effective than erythromycin.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pneumopathie infectieuse
/
Infections à Pseudomonas
/
Infections de l'appareil respiratoire
Limites:
Animals
Langue:
En
Journal:
Vet Med Sci
Année:
2023
Type de document:
Article
Pays d'affiliation:
Iran
Pays de publication:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
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UNITED KINGDOM