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Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis.
Lightner, Amy L; Dadgar, Neda; Vaidya, Anil; Simon, Robert; Fulmer, Clifton; Siddiki, Hassan; Narayanan Menon, K V; Liu, Peter; Matthew Walsh, R.
Affiliation
  • Lightner AL; Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Dadgar N; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Vaidya A; Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Simon R; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Fulmer C; Department of Abdominal Transplantation, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Siddiki H; Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Narayanan Menon KV; Department of Pathology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Liu P; Department of Gastroenterology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
  • Matthew Walsh R; Department of Gastroenterology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Cell Biol Int ; 47(2): 467-479, 2023 Feb.
Article de En | MEDLINE | ID: mdl-36321586
ABSTRACT
Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common bile duct. Coculture of MSCs with cholangiocytes and hepatocytes showed in vitro improvement. Local delivery of MSCs into a single patient with progressive PSC was safe. Radiographic and endoscopic evaluation showed stable distribution of multifocal structuring in the early postoperative period. MSCs may be effective for the treatment of PSC.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Angiocholite sclérosante / Cellules souches mésenchymateuses Limites: Humans Langue: En Journal: Cell Biol Int Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Angiocholite sclérosante / Cellules souches mésenchymateuses Limites: Humans Langue: En Journal: Cell Biol Int Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique