An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis.

Lesage, Raphaëlle; Ferrao Blanco, Mauricio N; Narcisi, Roberto; Welting, Tim; van Osch, Gerjo J V M; Geris, Liesbet

Lesage, Raphaëlle; Ferrao Blanco, Mauricio N; Narcisi, Roberto; Welting, Tim; van Osch, Gerjo J V M; Geris, Liesbet.

Affiliation

Lesage R; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium.
Ferrao Blanco MN; Biomechanics Section, KU Leuven, Leuven, Belgium.
Narcisi R; Department of Orthopaedics and Sports Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Welting T; Department of Orthopaedics and Sports Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
van Osch GJVM; Orthopedic Surgery Department, UMC+, Maastricht, the Netherlands.
Geris L; Department of Orthopaedics and Sports Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

BMC Biol ; 20(1): 253, 2022 11 09.

Article de En | MEDLINE | ID: mdl-36352408

Sujet(s)
Mots clés

Chondrocyte hypertrophy; Computational modeling; Drug targets; In vitro validation; Network of signal transduction; Osteoarthritis; Regulatory network inference; Virtual cell

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Arthrose / Cartilage articulaire Type d'étude: Prognostic_studies Limites: Animals / Humans Langue: En Journal: BMC Biol Sujet du journal: BIOLOGIA Année: 2022 Type de document: Article Pays d'affiliation: Belgique Pays de publication: Royaume-Uni

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