Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-<i>d</i>]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors.

Salem, Ibrahim M; Mostafa, Samia M; Salama, Ismail; El-Sabbagh, Osama I; Hegazy, Wael A H; Ibrahim, Tarek S

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors.

Salem, Ibrahim M; Mostafa, Samia M; Salama, Ismail; El-Sabbagh, Osama I; Hegazy, Wael A H; Ibrahim, Tarek S.

Affiliation

Salem IM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Mostafa SM; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Salama I; Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
El-Sabbagh OI; Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Hegazy WAH; Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Ibrahim TS; Pharmacy Program, Department of Pharmaceutical Sciences, Oman College of Health Sciences, Muscat, Oman.

J Enzyme Inhib Med Chem ; 38(1): 203-215, 2023 Dec.

Article de En | MEDLINE | ID: mdl-36382444

Sujet(s)
Mots clés

N-acyl amino acids; DHFR inhibition; MCF-7 breast cancer cell line; Pyrazolo[34-d]pyrimidine; methotrexate

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein / Antifoliques / Antinéoplasiques Limites: Female / Humans Langue: En Journal: J Enzyme Inhib Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: Égypte

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