Compensatory epistasis maintains ACE2 affinity in SARS-CoV-2 Omicron BA.1.

Moulana, Alief; Dupic, Thomas; Phillips, Angela M; Chang, Jeffrey; Nieves, Serafina; Roffler, Anne A; Greaney, Allison J; Starr, Tyler N; Bloom, Jesse D; Desai, Michael M

Moulana, Alief; Dupic, Thomas; Phillips, Angela M; Chang, Jeffrey; Nieves, Serafina; Roffler, Anne A; Greaney, Allison J; Starr, Tyler N; Bloom, Jesse D; Desai, Michael M.

Affiliation

Moulana A; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.
Dupic T; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA.
Phillips AM; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, 02138, USA. angela.phillips@ucsf.edu.
Chang J; Department of Physics, Harvard University, Cambridge, MA, 02138, USA.
Nieves S; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, 02138, USA.
Roffler AA; Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, 02115, USA.
Greaney AJ; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Starr TN; Department of Genome Sciences, University of Washington, Seattle, WA, 98195, USA.
Bloom JD; Medical Scientist Training Program, University of Washington, Seattle, WA, 98195, USA.
Desai MM; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.

Nat Commun ; 13(1): 7011, 2022 11 16.

Article de En | MEDLINE | ID: mdl-36384919

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Angiotensin-converting enzyme 2 / COVID-19 Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2022 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni

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