Inclusion body myositis: from genetics to clinical trials.
J Neurol
; 270(3): 1787-1797, 2023 Mar.
Article
de En
| MEDLINE
| ID: mdl-36399165
ABSTRACT
Inclusion body myositis (IBM) belongs to the group of idiopathic inflammatory myopathies and is characterized by a slowly progressive disease course with asymmetric muscle weakness of predominantly the finger flexors and knee extensors. The disease leads to severe disability and most patients lose ambulation due to lack of curative or disease-modifying treatment options. Despite some genes reported to be associated with hereditary IBM (a distinct group of conditions), data on the genetic susceptibility of sporadic IBM are very limited. This review gives an overview of the disease and focuses on the current genetic knowledge and potential therapeutic implications.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Myosite à inclusions
/
Myosite
Limites:
Humans
Langue:
En
Journal:
J Neurol
Année:
2023
Type de document:
Article
Pays d'affiliation:
Royaume-Uni