Six New Constituents from the Fruit of Hypericum patulum and Their Anti-Inflammatory Activity.
Chem Biodivers
; 20(1): e202200900, 2023 Jan.
Article
de En
| MEDLINE
| ID: mdl-36404281
Four new xanthone glucosides, 3-hydroxy-2-methoxyxanthone-4-O-ß-D-glucopyranoside (1), 4,8-dihydroxy-2-methoxyxanthone-3-O-ß-D-glucopyranoside (2), 2-methoxyxanthone-5-O-ß-D-glucopyranoside (3), 4-hydroxy-2-methoxyxanthone-3-O-ß-D-glucopyranoside (4), a new phenolic acid, 4,4'-dihydroxy-3,3'-imino-di-benzoic acid monomethyl ester (5), and a new isoquinoline, methyl 6-hydroxy-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxylate (6) were isolated from the fruit of Hypericum patulum. The structural elucidation of the isolated compounds was primarily based on HR-ESI-MS, UV, IR, 1D and 2D NMR. All compounds were evaluated for their inhibitory effect against LPS-induced NO production in RAW 264.7 cells. Compoundâ
2, 3 exhibited moderate inhibitory activity against NO production.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hypericum
Langue:
En
Journal:
Chem Biodivers
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Suisse