Microbiota-immune-brain interactions: A lifespan perspective.
Curr Opin Neurobiol
; 78: 102652, 2023 02.
Article
de En
| MEDLINE
| ID: mdl-36463579
ABSTRACT
There is growing appreciation of key roles of the gut microbiota in maintaining homeostasis and influencing brain and behaviour at critical windows across the lifespan. Mounting evidence suggests that communication between the gut and the brain could be the key to understanding multiple neuropsychiatric disorders, with the immune system coming to the forefront as an important mechanistic mediator. Throughout the lifespan, the immune system exchanges continuous reciprocal signals with the central nervous system. Intestinal microbial cues alter immune mediators with consequences for host neurophysiology and behaviour. Several factors challenge the gut microbiota composition, which in response release molecules with neuro- and immuno-active potential that are crucial for adequate neuro-immune interactions. In this review, multiple factors contributing to the upkeep of the fine balance between health and disease of these systems are discussed, and we elucidate the potential mechanistic implications for the gut microbiota inputs on host brain and behaviour across the lifespan.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Microbiote
/
Microbiome gastro-intestinal
Langue:
En
Journal:
Curr Opin Neurobiol
Sujet du journal:
BIOLOGIA
/
NEUROLOGIA
Année:
2023
Type de document:
Article