DYNAMICS OF FIBROTIC CHANGES IN THE LIVER AFTER THE SUCCESSFUL ERADICATION OF HEPATITIS C VIRUS IN PATIENTS WITH NAFLD.
Wiad Lek
; 75(10): 2392-2396, 2022.
Article
de En
| MEDLINE
| ID: mdl-36472266
ABSTRACT
OBJECTIVE:
Theaim:
To assess the dynamics of serum levels of angiopoietin-2 and transforming growth factor-ß1 in patients with chronic hepatitis C (CHC) with concomitant nonalcoholic fatty liver disease (NAFLD) after successful DAAs. PATIENTS ANDMETHODS:
Materials andmethods:
82 patients with CHC were examined, of which 56 were diagnosed with NAFLD and increased body weight. Ang-2, TGF-ß1, leptin, adiponectin, and the degree of liver fibrosis were determined for all participants. The patients were divided into groups 1 gr. (n=23) - CHС + increased body weight + hepatic steatosis, 2 gr. (n=33) - СÐС + increased body weight + nonalcoholic steatohepatitis, 3rd gr. (n=26) - CHC. All patients received DAAs for 12 weeks.RESULTS:
Results:
From 82 patients F3-4 had 31 people, F1-2 - 25, F0-1 - 11, F0 -15 patients. F3-4 and steatosis S2-3 (p<0.05) was more common in patients of 2 gr.. Serum Ang-2 levels were higher (p<0.05) in patients of 2 gr. with F3-4, than in patients with F0-2. Fibrosis regression occurred more often in patients with 1 and 3 gr. with F1-2 than in patients 2 gr. and F3-4 and was accompanied by a decrease in Ang-2 and TGF-ß1 levels.CONCLUSION:
Conclusions:
High levels of Ang-2 and TGF-ß1 are registered in patients with CHC+NAFLD, which correlate with the degree of liver fibrosis and significantly decrease after successful DAAs in patients with low initial stages of liver fibrosis and normal body weight.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hépatite C chronique
/
Stéatose hépatique non alcoolique
Limites:
Humans
Langue:
En
Journal:
Wiad Lek
Sujet du journal:
MEDICINA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Ukraine