Clinical Significance of Methyltransferase-like 16 Expression in Epithelial Ovarian Cancer.
J Coll Physicians Surg Pak
; 32(12): 1576-1580, 2022 Dec.
Article
de En
| MEDLINE
| ID: mdl-36474378
ABSTRACT
OBJECTIVE:
To detect methyltransferase-like (METTL) 16 expression in epithelial ovarian cancer (EOC) by immunohistochemistry (IHC), and its relationship with clinicohistopathological parameters and prognosis. STUDYDESIGN:
Observational study. PLACE AND DURATION OF STUDY Department of Gynaecology and Pathology, The First Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), from February to June 2022.METHODOLOGY:
METTL16 expression in 115 EOC patients was evaluated by IHC. According to the immunoreactive score (IRS), scores <6 represented low expressions and ≥6 high expressions. Clinicopathologic data and follow-up information were collected for statistical evaluation.RESULTS:
METTL16 expression decreased in EOC (p = 0.001) and affected the poor prognosis of EOC patients. Low METTL16 patients expression had significantly higher frequencies of advanced FIGO stage, low grade, more lymph node metastasis, high CA125 levels, bilateral disease, distant metastasis, and high frequency of neural/vascular invasion compared to high METTL16 patients (p ≤0.001, <0.001, <0.001, 0.017, 0.027, <0.001, and 0.010, respectively). The survival analysis showed that the overall survival (p <0.0001) as well as the disease-free survival (p <0.0001) were remarkably shorter in low METTL16 patients compared to high METTL16 patients, suggesting worse survival.CONCLUSION:
There was a clear association between the expression of METTL16, poor prognostic factors, and lower survival of EOC patients, suggesting that it might exert a vital effect on the malignant progression / prognosis of EOC. KEY WORDS Epithelial ovarian cancer (EOC), METTL16, Immunohistochemistry, Prognosis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de l'ovaire
/
Methyltransferases
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites:
Female
/
Humans
Langue:
En
Journal:
J Coll Physicians Surg Pak
Sujet du journal:
MEDICINA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine