Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature.

Coll-Bonfill, Nuria; Mahajan, Urvashi; Shashkova, Elena V; Lin, Chien-Jung; Mecham, Robert P; Gonzalo, Susana

Coll-Bonfill, Nuria; Mahajan, Urvashi; Shashkova, Elena V; Lin, Chien-Jung; Mecham, Robert P; Gonzalo, Susana.

Affiliation

Coll-Bonfill N; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 S Grand Blvd, St Louis, MO, 63104, USA.
Mahajan U; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 S Grand Blvd, St Louis, MO, 63104, USA.
Shashkova EV; Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, 1100 S Grand Blvd, St Louis, MO, 63104, USA.
Lin CJ; Cell Biology and Physiology Department & Department of Medicine, Washington University School of Medicine, St Louis, MO, 63108, USA.
Mecham RP; Department of Internal Medicine, Cardiovascular Division, Saint Louis University School of Medicine, St Louis, MO, 63104, USA.
Gonzalo S; Cell Biology and Physiology Department & Department of Medicine, Washington University School of Medicine, St Louis, MO, 63108, USA.

Geroscience ; 45(2): 965-982, 2023 04.

Article de En | MEDLINE | ID: mdl-36482259

Sujet(s)
Mots clés

Cardiovascular disease; Genomic instability; Lamins; Progeria; Replication stress; Telomere fragility

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Progeria / Muscles lisses vasculaires Type d'étude: Risk_factors_studies Limites: Animals / Humans Langue: En Journal: Geroscience Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Suisse

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