Cost-benefit analysis of rotavirus vaccine included in the national immunization program in China.
Vaccine
; 41(2): 547-554, 2023 01 09.
Article
de En
| MEDLINE
| ID: mdl-36503856
ABSTRACT
BACKGROUND:
Globally, rotavirus is a leading cause of severe acute gastroenteritis among children aged under 5 years and has a significant economic cost. Currently, rotavirus vaccines are only included in the private market in China. This study aimed to assess the cost-benefit of including a three-dose rotavirus vaccine in China's National Immunization Program (NIP).METHODS:
A decision tree Markov model was constructed to evaluate the cost-benefit of universal immunization with three doses of rotavirus vaccine for a 2019 birth cohort of Chinese children. Costs of the universal vaccination program included vaccine price, vaccine wastage, vaccine administration, and indirect costs. All costs were discounted at 3 % per year and converted from 2019 Chinese Yuan to 2019 USD using the 2019 exchange rate.RESULTS:
For the 2019 birth cohort of Chinese infants, inclusion of RotaTeq in NIP was estimated to prevent 5,677,911 cases of rotavirus infection, with net savings of $1.1 billion in total societal costs. A cost of $17.55 per vaccine dose was the threshold at which inclusion of rotavirus vaccine in NIP would be cost-saving.CONCLUSIONS:
Introducing rotavirus vaccine into the China NIP would have significant costs from a societal perspective at the current private market price.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infections à rotavirus
/
Rotavirus
/
Vaccins anti-rotavirus
Type d'étude:
Health_economic_evaluation
/
Prognostic_studies
Limites:
Child
/
Humans
/
Infant
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Vaccine
Année:
2023
Type de document:
Article