Associations of early life phthalate exposures with adolescent lipid levels and insulin resistance: The HOME Study.
Int J Hyg Environ Health
; 248: 114102, 2023 03.
Article
de En
| MEDLINE
| ID: mdl-36527833
ABSTRACT
BACKGROUND:
Early-life phthalate exposures may disrupt metabolic processes; however few prospective studies have assessed whether these associations extend to cardiometabolic outcomes during adolescence.METHODS:
Among 183 mother-adolescent pairs in a prospective cohort study that enrolled pregnant women in Cincinnati, OH (2003-2006), we quantified nine phthalate metabolites in spot urine samples collected twice from mothers during pregnancy and up to seven times from children. At age 12 years, we assessed triglycerides, high-density (HDL) and low-density (LDL) lipoprotein cholesterol, insulin, and glucose from fasting serum samples and calculated homeostatic model assessment of insulin resistance (HOMA-IR). Using multiple informant models, we estimated covariate-adjusted associations between urinary phthalate concentrations at each time period and cardiometabolic biomarkers at age 12 years, including modification by child sex.RESULTS:
Although most associations were weak or null, monoethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono-isobutyl phthalate (MiBP), and monobenzyl phthalate (MBzP) concentrations were generally associated with lower LDL at age 12 years. A 10-fold increase in 4- and 12-year MEP was associated with -15.3 mg/dL (95% CI 27.5, -3.13 mg/dL) and -11.8 mg/dL (-22.0, -1.51 mg/dL) lower LDL, respectively. Discrepant associations were observed in females versus males a 10-fold increase in 3-year MEP concentrations was associated with 12.0 mg/dL (95% CI 7.11, 31.1 mg/dL) higher LDL levels in males and -30.4 mg/dL (95% CI 50.9, -9.8 mg/dL) lower LDL levels in females. Some urinary phthalate concentrations were cross-sectionally associated with HOMA-IR.CONCLUSIONS:
Early-life phthalate biomarker concentrations may be inversely associated with LDL during early adolescence in an exposure-period and sex-dependent manner.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acides phtaliques
/
Insulinorésistance
/
Maladies cardiovasculaires
/
Polluants environnementaux
Type d'étude:
Observational_studies
Limites:
Adolescent
/
Child
/
Female
/
Humans
/
Male
/
Pregnancy
Langue:
En
Journal:
Int J Hyg Environ Health
Sujet du journal:
SAUDE AMBIENTAL
/
SAUDE PUBLICA
Année:
2023
Type de document:
Article