Engineering an inhibitor-resistant human CSF1R variant for microglia replacement.

Chadarevian, Jean Paul; Lombroso, Sonia I; Peet, Graham C; Hasselmann, Jonathan; Tu, Christina; Marzan, Dave E; Capocchi, Joia; Purnell, Freddy S; Nemec, Kelsey M; Lahian, Alina; Escobar, Adrian; England, Whitney; Chaluvadi, Sai; O'Brien, Carleigh A; Yaqoob, Fazeela; Aisenberg, William H; Porras-Paniagua, Matias; Bennett, Mariko L; Davtyan, Hayk; Spitale, Robert C; Blurton-Jones, Mathew; Bennett, F Chris

Chadarevian, Jean Paul; Lombroso, Sonia I; Peet, Graham C; Hasselmann, Jonathan; Tu, Christina; Marzan, Dave E; Capocchi, Joia; Purnell, Freddy S; Nemec, Kelsey M; Lahian, Alina; Escobar, Adrian; England, Whitney; Chaluvadi, Sai; O'Brien, Carleigh A; Yaqoob, Fazeela; Aisenberg, William H; Porras-Paniagua, Matias; Bennett, Mariko L; Davtyan, Hayk; Spitale, Robert C; Blurton-Jones, Mathew; Bennett, F Chris.

Affiliation

Chadarevian JP; Department of Neurobiology & Behavior, University of California, Irvine , Irvine, CA, USA.
Lombroso SI; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA, USA.
Peet GC; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
Hasselmann J; Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.
Tu C; Pharmacology Graduate Group, Biomedical Graduate Studies Program, University of Pennsylvania , Philadelphia, PA, USA.
Marzan DE; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania , Philadelphia, PA, USA.
Capocchi J; Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.
Purnell FS; Neuroscience Graduate Program and Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus , Aurora, CO, USA.
Nemec KM; Department of Neurobiology & Behavior, University of California, Irvine , Irvine, CA, USA.
Lahian A; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
Escobar A; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA, USA.
England W; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
Chaluvadi S; Department of Biology, The College of New Jersey , Ewing, NJ, USA.
O'Brien CA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA, USA.
Yaqoob F; Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.
Aisenberg WH; Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.
Porras-Paniagua M; Department of Neuroscience, Perelman School of Medicine , Philadelphia, PA, USA.
Bennett ML; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine , Irvine, CA, USA.
Davtyan H; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
Spitale RC; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine , Irvine, CA, USA.
Blurton-Jones M; Department of Pharmaceutical Sciences, University of California, Irvine , Irvine, CA, USA.
Bennett FC; Department of Psychiatry, Perelman School of Medicine , University of Pennsylvania, Philadelphia, PA, USA.

J Exp Med ; 220(3)2023 03 06.

Article de En | MEDLINE | ID: mdl-36584406

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ingénierie des protéines / Récepteur de facteur de croissance granulocyte-macrophage / Microglie Limites: Animals / Humans Langue: En Journal: J Exp Med Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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