Cross-immunity against SARS-COV-2 variants of concern in naturally infected critically ill COVID-19 patients.

Fraser, Douglas D; Patel, Maitray A; Van Nynatten, Logan R; Martin, Claudio; Seney, Shannon L; Miller, Michael R; Daley, Mark; Slessarev, Marat; Cepinskas, Gediminas; Juneja, Ganeem K; Sabourin, Vanessa; Fox-Robichaud, Alison; Yeh, Calvin H; Kim, Paul Y; Badrnya, Sigrun; Oehler, Susanne; Miholits, Markus; Webb, Brian

Fraser, Douglas D; Patel, Maitray A; Van Nynatten, Logan R; Martin, Claudio; Seney, Shannon L; Miller, Michael R; Daley, Mark; Slessarev, Marat; Cepinskas, Gediminas; Juneja, Ganeem K; Sabourin, Vanessa; Fox-Robichaud, Alison; Yeh, Calvin H; Kim, Paul Y; Badrnya, Sigrun; Oehler, Susanne; Miholits, Markus; Webb, Brian.

Affiliation

Fraser DD; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Patel MA; Pediatrics, Western University, London, ON, N6A 3K7, Canada.
Van Nynatten LR; Clinical Neurological Sciences, Western University, London, ON, N6A 3K7, Canada.
Martin C; Physiology & Pharmacology, Western University, London, ON, N6A 3K7, Canada.
Seney SL; Epidemiology, Western University, London, ON, N6A 3K7, Canada.
Miller MR; Medicine, Western University, London, ON, N6A 3K7, Canada.
Daley M; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Slessarev M; Medicine, Western University, London, ON, N6A 3K7, Canada.
Cepinskas G; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Juneja GK; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Sabourin V; Pediatrics, Western University, London, ON, N6A 3K7, Canada.
Fox-Robichaud A; Epidemiology, Western University, London, ON, N6A 3K7, Canada.
Yeh CH; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Kim PY; Medicine, Western University, London, ON, N6A 3K7, Canada.
Badrnya S; Lawson Health Research Institute, London, ON, N6C 2R5, Canada.
Oehler S; Medical Biophysics, Western University, London, ON, N6A 3K7, Canada.
Miholits M; Medicine, McMaster University, Hamilton, ON, L8S 4L8, Canada.
Webb B; Thrombosis and Atherosclerosis Research Institute, Hamilton, ON, L8L 2X2, Canada.

Heliyon ; 9(1): e12704, 2023 Jan.

Article de En | MEDLINE | ID: mdl-36594041

Mots clés

ACE2, angiotensin-converting enzyme; AUC, area-under-the-curve; Adaptive immunity; Antibodies; COPD, chronic obstructive pulmonary disease; COVID-19; COVID-19, coronavirus disease 2019; ICU, intensive care unit; IQR, interquartile range; Intensive care units; MFI, median fluorescence intensity; MODS, multi-organ dysfunction score; Neutralizing; P/F, arterial partial pressure to inspired oxygen; RBD, receptor binding domain; REB, research ethics board; ROC, receiver operating characteristic; SARS-CoV-2; SARS-CoV-2 alpha variant; SARS-CoV-2 beta variant; SARS-CoV-2 delta variant; SARS-CoV-2 gamma variant; SOFA, sequential organ failure assessment; VOC, variants of concern; VTE, venous thromboembolism; WT, wild-type

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Prognostic_studies Langue: En Journal: Heliyon Année: 2023 Type de document: Article Pays d'affiliation: Canada Pays de publication: Royaume-Uni

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