Heat-not-burn tobacco products and cardiovascular risk reduction: A systematic review of randomized controlled trials.
Technol Health Care
; 31(4): 1457-1491, 2023.
Article
de En
| MEDLINE
| ID: mdl-36641697
ABSTRACT
BACKGROUND:
Heat-not-burn (HNB) technology by the U.S. Food and Drug Administration has been classified as a modified risk tobacco product, which can be a better option for those populations who cannot give up the habit of smoking. The outlook on the effects of these products is quite controversial in the scientific world.OBJECTIVE:
To present the effect of HNB tobacco products on the cardiovascular system, with reference to the existence of possible benefits of the technology.METHODS:
The literature search was conducted in PubMed/Medline, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases, with reliance on a well-defined guiding research statement. Quality appraisal was performed using the CASP checklist for randomized controlled trials.RESULTS:
The search of three databases identified 167 records, and after selection process, 25 randomized controlled trials were eligible for our study's criteria. Twenty studies investigated the effects of HNB products on biomarkers of clinical relevance. Five studies evaluated other functional heart parameters rather than biomarkers.CONCLUSION:
With HNB tobacco products, significant reductions were found in biomarkers of exposure and biological effect related to pathways involved in cardiovascular disease, including inflammation, oxidative stress, lipid metabolism, platelet function, and endothelial dysfunction.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies cardiovasculaires
/
Système cardiovasculaire
/
Produits du tabac
Type d'étude:
Clinical_trials
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limites:
Humans
Langue:
En
Journal:
Technol Health Care
Sujet du journal:
ENGENHARIA BIOMEDICA
/
SERVICOS DE SAUDE
Année:
2023
Type de document:
Article