A fluorescent probe based on a phenylalanine derivative is capable of sequential detection of Zn2+ and Cys/His.
J Biol Inorg Chem
; 28(2): 205-211, 2023 03.
Article
de En
| MEDLINE
| ID: mdl-36652011
ABSTRACT
A facile and dual fluorescent chemosensor (named 7-IDF) based on a phenylalanine derivative with an indole group was designed and synthesized. 7-IDF can selectively and sensitively detect Zn2+ via obvious fluorescence enhancement in an aqueous solution. Remarkably, the 7-IDF-Zn complex with blue luminescence has higher selectivity toward cysteine (Cys) and histidine (His) than for other amino acids. Intriguingly, 7-IDF can also be used as an excellent probe to detect Zn2+ in real water samples. Moreover, 7-IDF and 7-IDF-Zn possess excellent biocompatibility and cell permeability, and 7-IDF can consecutively detect Zn2+ and Cys/His in Hela cells through fluorescence imaging experiments. This study suggests that the phenylalanine-based chemosensor possesses great potential applications for the sequential detection of Zn2+ and Cys/His in biosystems.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cystéine
/
Colorants fluorescents
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
J Biol Inorg Chem
Sujet du journal:
BIOQUIMICA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Chine