Proline-Proline Dyad in the Fusion Peptide of the Murine ß-Coronavirus Spike Protein's S2 Domain Modulates Its Neuroglial Tropism.

Safiriyu, Abass Alao; Mulchandani, Vaishali; Anakkacheri, Mohammed Nahaf; Pal, Debnath; Das Sarma, Jayasri

Safiriyu, Abass Alao; Mulchandani, Vaishali; Anakkacheri, Mohammed Nahaf; Pal, Debnath; Das Sarma, Jayasri.

Affiliation

Safiriyu AA; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Mulchandani V; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Anakkacheri MN; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.
Pal D; Department of Computational and Data Sciences, Indian Institute of Science, Bengaluru 560012, India.
Das Sarma J; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India.

Viruses ; 15(1)2023 01 12.

Article de En | MEDLINE | ID: mdl-36680255

Sujet(s)
Mots clés

RSMHV2(PP); Spike protein; cell-to-cell fusion (fusogenicity); fusion peptide (FP); fusion-mutant strain RSA59(P); gliopathy; neuroglial-tropism; neuropathogenesis; recombinant strain MHV-2/RSMHV2; recombinant strain mouse hepatitis virus-A59/RSA59; ß-coronavirus

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Virus de l'hépatite murine / Tropisme viral / Glycoprotéine de spicule des coronavirus Limites: Animals Langue: En Journal: Viruses Année: 2023 Type de document: Article Pays d'affiliation: Inde Pays de publication: Suisse

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