Neural correlates of neuroticism: A coordinate-based meta-analysis of resting-state functional brain imaging studies.
Neurosci Biobehav Rev
; 146: 105055, 2023 03.
Article
de En
| MEDLINE
| ID: mdl-36681370
ABSTRACT
Neuroticism is one of the most robust higher-order personality traits associated with negative emotionality and risk of mental disorders. Many studies have investigated relationships between neuroticism and the brain, but the results have been inconsistent. We conducted a meta-analysis of whole-brain resting-state functional neuroimaging studies to identify the most stable neurofunctional substrates of neuroticism. We found stable significant positive correlations between neuroticism and resting-state brain activity in the left middle temporal gyrus (MTG), left striatum, and right hippocampus. In contrast, resting-state brain activity in the left superior temporal gyrus (STG) and right supramarginal gyrus (SMG) was negatively associated with neuroticism. Additionally, meta-regression analysis revealed brain regions in which sex and age moderated the link of spontaneous activity with neuroticism. This is the first study to provide a comprehensive understanding of resting-state brain activity correlates of neuroticism, and the findings may be useful for the targeting of specific brain regions for interventions to decrease the risks of mental health problems.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cartographie cérébrale
/
Imagerie par résonance magnétique
Type d'étude:
Prognostic_studies
/
Systematic_reviews
Limites:
Humans
Langue:
En
Journal:
Neurosci Biobehav Rev
Année:
2023
Type de document:
Article
Pays d'affiliation:
Chine