Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies.
Trends Immunol
; 44(3): 217-230, 2023 03.
Article
de En
| MEDLINE
| ID: mdl-36709082
ABSTRACT
Obesity is associated with the development of various complications, including diabetes, atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune responses. Recent insights have revealed that the availability of nutrients is a key determinant of innate immune cell function. Although the presence of obesity is associated with overnutrition of macronutrients, several micronutrient deficiencies, including Vitamin D and zinc, are often present. Micronutrients have been attributed important immunomodulatory roles. In this review, we summarize current knowledge of the immunomodulatory effects of Vitamin D and zinc. We also suggest future lines of research to further improve our understanding of these micronutrients; this may serve as a stepping-stone to explore micronutrient supplementation to improve innate immune cell function during obesity.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Micronutriments
/
Compléments alimentaires
Limites:
Humans
Langue:
En
Journal:
Trends Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Pays-Bas