EEG lexicality effect predicts clinical outcome in disorders of consciousness.
Ann Neurol
; 93(4): 762-767, 2023 04.
Article
de En
| MEDLINE
| ID: mdl-36754832
ABSTRACT
This study aimed at probing covert language processing in patients with disorders of consciousness. An auditory paradigm contrasting words to pronounceable pseudowords was designed, while recording bedside electroencephalogram and computing the two main correlates of lexicality N400 and late positive component (LPC). Healthy volunteers and 19 patients, 10 in a minimally conscious state and 9 in a vegetative state (also coined unresponsive wakefulness syndrome), were recorded. N400 was present in all groups, whereas LPC was only present in the healthy volunteers and minimally conscious state groups. At the individual level, an unprecedented detection rate of N400 and LPC was reached, and LPC predicted overt cognitive improvement at 6 months. ANN NEUROL 2023;93762-767.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
État végétatif persistant
/
Électroencéphalographie
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
Langue:
En
Journal:
Ann Neurol
Année:
2023
Type de document:
Article
Pays d'affiliation:
France