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Quantifying health-related quality of life in Malaysian type 2 diabetes: focusing on complication types and severity.
Tan, Michelle Hwee Pheng; Ong, Siew Chin; Vasan Thakumar, Annushiah; Mustafa, Norlaila.
Affiliation
  • Tan MHP; Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Science, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.
  • Ong SC; Pharmacy Department, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia, 56000, Cheras, Kuala Lumpur, Malaysia.
  • Vasan Thakumar A; Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Science, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia. siewchinong@usm.my.
  • Mustafa N; Discipline of Social and Administrative Pharmacy, School of Pharmaceutical Science, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.
Qual Life Res ; 32(7): 1925-1941, 2023 Jul.
Article de En | MEDLINE | ID: mdl-36781810
PURPOSE: There is a knowledge gap of health utility values for Type 2 Diabetes Mellitus (T2DM) complications in Malaysia. This study aimed to estimate EQ-5D-5L utility values and evaluate health-related quality of life (HRQoL) for Malaysian T2DM associated with complications and clinical characteristics. METHODS: A cross-sectional study was conducted on T2DM patients at a tertiary hospital outpatient using the Malay and English version of the EQ-5D-5L questionnaire. Health utility values were derived using the Malaysian EQ-5D-5L value set. Ordinary least squares (OLS) multivariable regression model was used to estimate the health utility decrements associated with T2DM-related complications and clinical characteristics. RESULTS: A total of 513 T2DM patients were recruited. Overall, pain was the most affected of all five EQ-5D-5L dimensions. Patients with foot ulcer, amputation, severe heart failure and frequent hypoglycemia reported more problems collectively in all EQ-5D-5L dimensions. Older age, lower education level, longer duration of T2DM, urine protein creatine index (UPCI) > 0.02 g/mmol, and injection therapy were significantly associated with lower EQ-5D-5L utility values (p < 0.004, Bonferroni adjusted). The lowest unadjusted utility values were reported for severe heart failure 0.65 (interquartile range, IQR 0.50), frequent hypoglycemia 0.74 (0.22) and being amputated 0.78 (0.47). In the multivariable regression model after controlling for sociodemographic and clinical characteristics, the largest utility value decrement was observed for amputation (- 0.158, SE 0.087, p = 0.05), frequent hypoglycemia (- 0.101, SE 0.030, p = 0.001), myocardial infarction (-0.050, SE 0.022, p = 0.022) and obesity (-0.034, SE 0.016, p = 0.029). CONCLUSION: Larger utility value decrements were found for severe stages of complications. These findings suggest the value of defining severity of complications in utility elicitation studies. The utility decrement quantified for different T2DM complication severity will be useful for economic evaluations within diabetic-related fields.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Diabète de type 2 / Défaillance cardiaque / Hypoglycémie Type d'étude: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limites: Humans Langue: En Journal: Qual Life Res Sujet du journal: REABILITACAO / TERAPEUTICA Année: 2023 Type de document: Article Pays d'affiliation: Malaisie Pays de publication: Pays-Bas

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Diabète de type 2 / Défaillance cardiaque / Hypoglycémie Type d'étude: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspects: Patient_preference Limites: Humans Langue: En Journal: Qual Life Res Sujet du journal: REABILITACAO / TERAPEUTICA Année: 2023 Type de document: Article Pays d'affiliation: Malaisie Pays de publication: Pays-Bas