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Redox-dual-sensitive multiblock copolymer vesicles with disulfide-enabled sequential drug delivery.
Cheng, Cheng; Ma, Jiayun; Zhao, Jinling; Lu, Haiying; Liu, Yang; He, Chuanshi; Lu, Man; Yin, Xiaohong; Li, Jianshu; Ding, Mingming.
Affiliation
  • Cheng C; Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
  • Ma J; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
  • Zhao J; Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
  • Lu H; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
  • Liu Y; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
  • He C; Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
  • Lu M; College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.
  • Yin X; Department of Ultrasound Medical Center, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Li J; Department of Ultrasound Medical Center, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • Ding M; Science and Technology Innovation Center, Guangyuan Central Hospital, Guangyuan 628000, China.
J Mater Chem B ; 11(12): 2631-2637, 2023 03 22.
Article de En | MEDLINE | ID: mdl-36794489
ABSTRACT
Based on disulfide-enriched multiblock copolymer vesicles, we present a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX·HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Systèmes de délivrance de médicaments / Disulfures Type d'étude: Diagnostic_studies Langue: En Journal: J Mater Chem B Année: 2023 Type de document: Article Pays d'affiliation: Chine
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Systèmes de délivrance de médicaments / Disulfures Type d'étude: Diagnostic_studies Langue: En Journal: J Mater Chem B Année: 2023 Type de document: Article Pays d'affiliation: Chine