Attenuation of indoxyl sulfate-induced cell damage by cinchonidine-a Cinchona alkaloid-through the downregulation of p53 signaling pathway by promoting MDM2 cytoplasmic-nuclear shuttling in endothelial cells.

Teng, Ruei-Dun; Yang, Chih-Hao; Chung, Chi-Li; Sheu, Joen-Rong; Hsieh, Cheng-Ying

Teng, Ruei-Dun; Yang, Chih-Hao; Chung, Chi-Li; Sheu, Joen-Rong; Hsieh, Cheng-Ying.

Affiliation

Teng RD; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Yang CH; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Chung CL; Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; School of Respiratory Therapy, Col
Sheu JR; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Hsieh CY; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: hsiehcy@tmu.edu.tw.

Life Sci ; 318: 121477, 2023 Apr 01.

Article de En | MEDLINE | ID: mdl-36796718

Sujet(s)
Mots clés

Cinchonidine; Endothelial dysfunction; Indoxyl sulfate; MDM2; Renocardiac syndromes; p53

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Alcaloïdes de Cinchona / Syndrome cardiorénal Limites: Humans Langue: En Journal: Life Sci Année: 2023 Type de document: Article Pays d'affiliation: Taïwan Pays de publication: Pays-Bas

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