Inflammation-modulating antibacterial hydrogel sustained release asiaticoside for infection wound healing.
Biomater Adv
; 147: 213302, 2023 Apr.
Article
de En
| MEDLINE
| ID: mdl-36841110
ABSTRACT
Wound infection and persistent inflammation are considered to be the main reasons for hindering wound healing. In this study, we developed an innovative hydrogel dressing, EPL-DA/ODEX/AMs, as a platform to inhibit bacteria and inflammation and promote wound healing. Polylysine (EPL) has cationic properties and can effectively disrupt bacterial cell membranes for antibacterial purposes. Polylysine-grafted levodopa (EPL-DA) with abundant amino and catechol groups can be cross-linked with oxidized dextran through Schiff base reaction to form antibacterial hydrogels with good adhesion and mechanical properties. In addition, asiaticoside, which can effectively inhibit inflammation and promote collagen regeneration, is made into PLGA microspheres to effectively deliver asiaticoside to the wound. The innovative antibacterial hydrogel of EPL-DA/ODEX/AMs may become a competitive wound dressing for infected wound.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polylysine
/
Hydrogels
Limites:
Humans
Langue:
En
Journal:
Biomater Adv
Année:
2023
Type de document:
Article
Pays d'affiliation:
Chine