Antioxidant and cytotoxic activities of quinones from Cetraria laevigata.
Nat Prod Res
; 38(4): 685-689, 2024.
Article
de En
| MEDLINE
| ID: mdl-36890791
ABSTRACT
Chemical investigation of the extracts obtained from the red thallus tips from Cetraria laevigata resulted in the isolation of five known quinoid pigments identified by FT-IR, UV, NMR, MS methods and by comparison with literature data (skyrin (1), 3-ethyl-2,7-dihydroxynaphthazarin (2), graciliformin (3), cuculoquinone (4) and islandoquinone (5)). An antioxidant capacity of compounds 1-5 were evaluated and compared with quercetin using a lipid peroxidation inhibitory assay and superoxide radical (SOR), nitric oxide radical (NOR), 1,1-diphenyl-2-picrylhydrazine (DPPH), 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) (ABTS) scavenging assays. Compounds 2, 4 and 5 were far more active they demonstrated the antioxidant capacity in various test assays with the IC50 values 5-409 µM comparable to the flavonoid quercetin. While, the isolated quinones (1-5) exhibited weak cytotoxicity in human cancer cell line A549 assessed by MTT assay.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Parmeliaceae
/
Antinéoplasiques
/
Antioxydants
Limites:
Humans
Langue:
En
Journal:
Nat Prod Res
Année:
2024
Type de document:
Article
Pays d'affiliation:
Russie