Advancing blood transfusion safety using molecular detection in the country of Georgia.
Transfus Clin Biol
; 30(3): 307-313, 2023 Aug.
Article
de En
| MEDLINE
| ID: mdl-36907246
ABSTRACT
BACKGROUND:
In 2015, the country of Georgia initiated its hepatitis C virus (HCV) elimination program. Given a high background incidence of HCV infection, centralized nucleic acid testing (NAT) of blood donations was prioritized for implementation. STUDY DESIGN ANDMETHODS:
Multiplex NAT screening for HIV, HCV and hepatitis B virus (HBV) was launched in January 2020. An analysis was conducted of serological and NAT donor/donation data for the first year of screening (through December 2020).RESULTS:
A total of 54,116 donations representing 39,164 unique donors were evaluated. Overall, 671 donors (1.7%) tested positive for at least one infectious marker by serology or NAT, with the highest prevalence among donors aged 40-49 years (2.5%; n = 200), male (1.9%; n = 524), replacement (2.8%; n = 153) and first time (2.1%; n = 642) donors. Sixty donations were seronegative but NAT positive, and therefore would not have been found by traditional serology testing alone. These were more likely among female vs. male (adjusted odds ratio [aOR] 2.06; 95% confidence interval [95%CI] 1.05-4.05), paid (aOR 10.15; 95%CI 2.80-36.86) or voluntary (aOR 4.30; 95%CI 1.27-14.56) vs replacement, and repeat vs. first time (aOR 13.98; 95%CI 4.06-48.12) donors. On repeat serological testing (including HBV core antibody [HBcAb] testing), 6 HBV + donations, 5 HCV + donations and 1 HIV + donations were deemed NAT yield (detected through the implementation of NAT, and would have otherwise been missed by serology screening alone).CONCLUSION:
This analysis offers a regional model for NAT implementation, demonstrating the feasibility and clinical utility in a nationwide blood program.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Infections à VIH
/
Hépatite C
/
Hépatite B
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Transfus Clin Biol
Sujet du journal:
HEMATOLOGIA
Année:
2023
Type de document:
Article