Novel therapeutic approaches to target neurodegeneration.
Br J Pharmacol
; 180(13): 1651-1673, 2023 07.
Article
de En
| MEDLINE
| ID: mdl-36965025
ABSTRACT
Ageing is the main risk factor common to most primary neurodegenerative disorders. Indeed, age-related brain alterations have been long considered to predispose to neurodegeneration. Although protein misfolding and the accumulation of toxic protein aggregates have been considered as causative events in neurodegeneration, several other biological pathways affected by brain ageing also contribute to pathogenesis. Here, we discuss the evidence showing the involvement of the mechanisms controlling neuronal structure, gene expression, autophagy, cell metabolism and neuroinflammation in the onset and progression of neurodegenerative disorders. Furthermore, we review the therapeutic strategies currently under development or as future approaches designed to normalize these pathways, which may then increase brain resilience to cope with toxic protein species. In addition to therapies targeting the insoluble protein aggregates specifically associated with each neurodegenerative disorder, these novel pharmacological approaches may be part of combined therapies designed to rescue brain function.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies neurodégénératives
/
Agrégats de protéines
Type d'étude:
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Br J Pharmacol
Année:
2023
Type de document:
Article
Pays d'affiliation:
Espagne