Transition Metal-free Selenium-mediated Aryl Amines via Reduction of Nitroarenes.
ChemSusChem
; 16(15): e202300086, 2023 Aug 07.
Article
de En
| MEDLINE
| ID: mdl-36971384
ABSTRACT
A scalable and operationally simple on water seleno-mediated reduction of nitroarenes to the respective aryl amines with NaBH4 is described. The reaction proceeds under transition metal-free conditions and is promoted by the formation of Na2 Se, which is the effective reducing agent involved in the mechanism. This mechanistic information enabled the development of a mild NaBH4 -free protocol for the selective reduction of nitro derivatives bearing labile moieties, including nitrocarbonyl compounds. The selenium-containing aqueous phase can be successfully reused up to four reduction cycles, thus further improving the efficiency of the protocol disclosed.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
ChemSusChem
Sujet du journal:
QUIMICA
/
TOXICOLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
Italie