Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies.

Germon, Zacary P; Sillar, Jonathan R; Mannan, Abdul; Duchatel, Ryan J; Staudt, Dilana; Murray, Heather C; Findlay, Izac J; Jackson, Evangeline R; McEwen, Holly P; Douglas, Alicia M; McLachlan, Tabitha; Schjenken, John E; Skerrett-Byrne, David A; Huang, Honggang; Melo-Braga, Marcella N; Plank, Maximilian W; Alvaro, Frank; Chamberlain, Janis; De Iuliis, Geoff; Aitken, R John; Nixon, Brett; Wei, Andrew H; Enjeti, Anoop K; Huang, Yizhou; Lock, Richard B; Larsen, Martin R; Lee, Heather; Vaghjiani, Vijesh; Cain, Jason E; de Bock, Charles E; Verrills, Nicole M; Dun, Matthew D

Germon, Zacary P; Sillar, Jonathan R; Mannan, Abdul; Duchatel, Ryan J; Staudt, Dilana; Murray, Heather C; Findlay, Izac J; Jackson, Evangeline R; McEwen, Holly P; Douglas, Alicia M; McLachlan, Tabitha; Schjenken, John E; Skerrett-Byrne, David A; Huang, Honggang; Melo-Braga, Marcella N; Plank, Maximilian W; Alvaro, Frank; Chamberlain, Janis; De Iuliis, Geoff; Aitken, R John; Nixon, Brett; Wei, Andrew H; Enjeti, Anoop K; Huang, Yizhou; Lock, Richard B; Larsen, Martin R; Lee, Heather; Vaghjiani, Vijesh; Cain, Jason E; de Bock, Charles E; Verrills, Nicole M; Dun, Matthew D.

Affiliation

Germon ZP; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Sillar JR; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Mannan A; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Duchatel RJ; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Staudt D; Department of Haematology, Calvary Mater Hospital, Waratah, NSW, Australia.
Murray HC; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Findlay IJ; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Jackson ER; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
McEwen HP; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Douglas AM; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
McLachlan T; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Schjenken JE; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Skerrett-Byrne DA; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Huang H; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Melo-Braga MN; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Plank MW; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Alvaro F; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Chamberlain J; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
De Iuliis G; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Aitken RJ; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Nixon B; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Wei AH; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
Enjeti AK; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Huang Y; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.
Lock RB; Priority Research Centre for Reproductive Science, School of Environmental and Life Sciences, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia.
Larsen MR; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.
Lee H; Department of Molecular Biology and Biochemistry, Protein Research Group, University of Southern Denmark, Odense, Denmark.
Vaghjiani V; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Cain JE; Cancer Signalling Research Group, School of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia.
de Bock CE; GlaxoSmithKline, Abbotsford, Victoria, Australia.
Verrills NM; Precision Medicine Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Dun MD; John Hunter Children's Hospital, New Lambton Heights, NSW, Australia.

Sci Signal ; 16(778): eabp9586, 2023 03 28.

Article de En | MEDLINE | ID: mdl-36976863

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Leucémie aigüe myéloïde / Cystéine Limites: Animals / Humans Langue: En Journal: Sci Signal Sujet du journal: CIENCIA / FISIOLOGIA Année: 2023 Type de document: Article Pays d'affiliation: Australie Pays de publication: États-Unis d'Amérique

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