Randomization, design and analysis for interdependency in aging research: no person or mouse is an island.
Nat Aging
; 2(12): 1101-1111, 2022 12.
Article
de En
| MEDLINE
| ID: mdl-37063472
ABSTRACT
Investigators traditionally use randomized designs and corresponding analysis procedures to make causal inferences about the effects of interventions, assuming independence between an individual's outcome and treatment assignment and the outcomes of other individuals in the study. Often, such independence may not hold. We provide examples of interdependency in model organism studies and human trials and group effects in aging research and then discuss methodologic issues and solutions. We group methodologic issues as they pertain to (1) single-stage individually randomized trials; (2) cluster-randomized controlled trials; (3) pseudo-cluster-randomized trials; (4) individually randomized group treatment; and (5) two-stage randomized designs. Although we present possible strategies for design and analysis to improve the rigor, accuracy and reproducibility of the science, we also acknowledge real-world constraints. Consequences of nonadherence, differential attrition or missing data, unintended exposure to multiple treatments and other practical realities can be reduced with careful planning, proper study designs and best practices.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Géroscience
Type d'étude:
Clinical_trials
/
Guideline
/
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Nat Aging
Année:
2022
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique