Direct correction of haemoglobin E ß-thalassaemia using base editors.

Badat, Mohsin; Ejaz, Ayesha; Hua, Peng; Rice, Siobhan; Zhang, Weijiao; Hentges, Lance D; Fisher, Christopher A; Denny, Nicholas; Schwessinger, Ron; Yasara, Nirmani; Roy, Noemi B A; Issa, Fadi; Roy, Andi; Telfer, Paul; Hughes, Jim; Mettananda, Sachith; Higgs, Douglas R; Davies, James O J

Badat, Mohsin; Ejaz, Ayesha; Hua, Peng; Rice, Siobhan; Zhang, Weijiao; Hentges, Lance D; Fisher, Christopher A; Denny, Nicholas; Schwessinger, Ron; Yasara, Nirmani; Roy, Noemi B A; Issa, Fadi; Roy, Andi; Telfer, Paul; Hughes, Jim; Mettananda, Sachith; Higgs, Douglas R; Davies, James O J.

Affiliation

Badat M; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Ejaz A; Department of Clinical Haematology, Royal London Hospital, Barts Health NHS Trust, London, UK.
Hua P; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Rice S; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Zhang W; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Hentges LD; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Fisher CA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Denny N; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Schwessinger R; MRC WIMM Centre for Computational Biology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Yasara N; Oxford National Institute of Health Research Biomedical Research Centre, University of Oxford, Oxford, UK.
Roy NBA; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Issa F; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Roy A; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Telfer P; Department of Paediatrics, University of Kelaniya, Kelaniya, Sri Lanka.
Hughes J; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Mettananda S; Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Higgs DR; MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Davies JOJ; Department of Paediatrics, University of Oxford, Oxford, UK.

Nat Commun ; 14(1): 2238, 2023 04 19.

Article de En | MEDLINE | ID: mdl-37076455

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Thalassémie / Hémoglobine E / Bêta-Thalassémie Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2023 Type de document: Article Pays d'affiliation: Royaume-Uni Pays de publication: Royaume-Uni

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