Quantitative Lipidomic Analysis of Serum Phospholipids Reveals Dissociable Markers of Alzheimer's Disease and Subcortical Cerebrovascular Disease.
J Alzheimers Dis
; 93(2): 665-682, 2023.
Article
de En
| MEDLINE
| ID: mdl-37092220
ABSTRACT
BACKGROUND:
Circulating phospholipid species have been shown to predict Alzheimer's disease (AD) prognosis but the link between phospholipid disturbances and subcortical small vessel cerebrovascular disease (CeVD) common in AD patients is not known.OBJECTIVE:
Mass-spectrometry lipidomics was applied to quantify serum diacyl, alkenyl (ether), alkyl, and lyso phospholipid species in individuals with extensive CeVD (nâ=â29), AD with minimal CeVD (nâ=â16), and AD with extensive CeVD (nâ=â14), and compared them to age-matched controls (nâ=â27). Memory was assessed using the California Verbal Learning Test. 3.0T MRI was used to assess hippocampal volume, atrophy, and white matter hyperintensity (WMH) volumes as manifestations of CeVD.RESULTS:
AD was associated with significantly higher concentrations of choline plasmalogen 180_181 and alkyl-phosphocholine 181. CeVD was associated with significantly lower lysophospholipids containing 160. Phospholipids containing arachidonic acid (AA) were associated with poorer memory in controls, whereas docosahexaenoic acid (DHA)-containing phospholipids were associated with better memory in individuals with AD+CeVD. In controls, DHA-containing phospholipids were associated with more atrophy, and phospholipids containing linoleic acid and AA were associated with less atrophy. Lysophospholipids containing 160, 180, and 181 were correlated with less atrophy in controls, and of these, alkyl-phosphocholine 181 was correlated with smaller WMH volumes. Conversely, 160_181 choline plasmalogen was correlated with greater WMH volumes in controls.CONCLUSION:
This study demonstrates discernable differences in circulating phospholipids in individuals with AD and CeVD, as well as new associations between phospholipid species with memory and brain structure that were specific to contexts of commonly comorbid vascular and neurodegenerative pathologies.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Angiopathies intracrâniennes
/
Maladie d'Alzheimer
/
Substance blanche
Limites:
Humans
Langue:
En
Journal:
J Alzheimers Dis
Sujet du journal:
GERIATRIA
/
NEUROLOGIA
Année:
2023
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique