Complement C3d/C4d Deposition on Platelets Correlates with 2'-O-Methoxyethyl Antisense Oligonucleotide-Induced Thrombocytopenia in Monkeys.

Shen, Lijiang; Wong, Andrea; Oneda, Satoru; Curtis, Brian R; Schroeder, Joe; Zanardi, Tom; Engelhardt, Jeffery A; Henry, Scott P; Narayanan, Padmakumar

Shen, Lijiang; Wong, Andrea; Oneda, Satoru; Curtis, Brian R; Schroeder, Joe; Zanardi, Tom; Engelhardt, Jeffery A; Henry, Scott P; Narayanan, Padmakumar.

Affiliation

Shen L; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Wong A; Altasciences Preclinical Seattle LLC, Everett, Washington, USA.
Oneda S; Altasciences Preclinical Seattle LLC, Everett, Washington, USA.
Curtis BR; Versiti Blood Center of Wisconsin, Milwaukee, Wisconsin, USA.
Schroeder J; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Zanardi T; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Engelhardt JA; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Henry SP; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.
Narayanan P; Nonclinical Development, Ionis Pharmaceuticals, Inc., Carlsbad, California, USA.

Nucleic Acid Ther ; 33(3): 209-225, 2023 06.

Article de En | MEDLINE | ID: mdl-37093125

Sujet(s)
Mots clés

2'-MOE ASO; complement; nonhuman primates; platelets

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Thrombopénie / Plaquettes Limites: Animals Langue: En Journal: Nucleic Acid Ther Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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