Efficient prime editing in mouse brain, liver and heart with dual AAVs.

Davis, Jessie R; Banskota, Samagya; Levy, Jonathan M; Newby, Gregory A; Wang, Xiao; Anzalone, Andrew V; Nelson, Andrew T; Chen, Peter J; Hennes, Andrew D; An, Meirui; Roh, Heejin; Randolph, Peyton B; Musunuru, Kiran; Liu, David R

Davis, Jessie R; Banskota, Samagya; Levy, Jonathan M; Newby, Gregory A; Wang, Xiao; Anzalone, Andrew V; Nelson, Andrew T; Chen, Peter J; Hennes, Andrew D; An, Meirui; Roh, Heejin; Randolph, Peyton B; Musunuru, Kiran; Liu, David R.

Affiliation

Davis JR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Banskota S; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Levy JM; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Wang X; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Anzalone AV; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Nelson AT; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Chen PJ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Hennes AD; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
An M; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Roh H; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Randolph PB; Howard Hughes Medical Institute, Harvard University, Cambridge, MA, USA.
Musunuru K; Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Liu DR; Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.

Nat Biotechnol ; 42(2): 253-264, 2024 Feb.

Article de En | MEDLINE | ID: mdl-37142705

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Édition de gène / RNA, Guide, CRISPR-Cas Systems Limites: Animals Langue: En Journal: Nat Biotechnol Sujet du journal: BIOTECNOLOGIA Année: 2024 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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