Coptisine modulates the pharmacokinetics of florfenicol by targeting CYP1A2, CYP2C11 and CYP3A1 in the liver and P-gp in the jejunum of rats: a pilot study.

Li, Si-Cong; Zhang, Min; Wang, Bin; Li, Xu-Ting; Liang, Ge

Li, Si-Cong; Zhang, Min; Wang, Bin; Li, Xu-Ting; Liang, Ge.

Affiliation

Li SC; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Zhang M; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Wang B; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.
Li XT; Veterinary Natural Medicine Research and GCP Experimental Animal Centre, Lezhi, P.R. China.
Liang G; Sichuan Key Laboratory of Animal Genetics and Breeding, Sichuan Animal Science Academy, Chengdu, P.R. China.

Xenobiotica ; 53(3): 207-214, 2023 Mar.

Article de En | MEDLINE | ID: mdl-37144948

Sujet(s)
Mots clés

Coptisine; Florfenicol; P-glycoprotein; cytochrome P450; pharmacokinetics

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Aryl hydrocarbon hydroxylases / Cytochrome P-450 CYP1A2 Limites: Animals Langue: En Journal: Xenobiotica Année: 2023 Type de document: Article Pays de publication: Royaume-Uni

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