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A Computationally Assisted Approach for Designing Wearable Biosensors toward Non-Invasive Personalized Molecular Analysis.
Mukasa, Daniel; Wang, Minqiang; Min, Jihong; Yang, Yiran; Solomon, Samuel A; Han, Hong; Ye, Cui; Gao, Wei.
Affiliation
  • Mukasa D; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Wang M; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Min J; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Yang Y; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Solomon SA; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Han H; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Ye C; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Gao W; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
Adv Mater ; 35(35): e2212161, 2023 Sep.
Article de En | MEDLINE | ID: mdl-37159949
ABSTRACT
Wearable sweat sensors have the potential to revolutionize precision medicine as they can non-invasively collect molecular information closely associated with an individual's health status. However, the majority of clinically relevant biomarkers cannot be continuously detected in situ using existing wearable approaches. Molecularly imprinted polymers (MIPs) are a promising candidate to address this challenge but haven't yet gained widespread use due to their complex design and optimization process yielding variable selectivity. Here, QuantumDock is introduced, an automated computational framework for universal MIP development toward wearable applications. QuantumDock utilizes density functional theory to probe molecular interactions between monomers and the target/interferent molecules to optimize selectivity, a fundamentally limiting factor for MIP development toward wearable sensing. A molecular docking approach is employed to explore a wide range of known and unknown monomers, and to identify the optimal monomer/cross-linker choice for subsequent MIP fabrication. Using an essential amino acid phenylalanine as the exemplar, experimental validation of QuantumDock is performed successfully using solution-synthesized MIP nanoparticles coupled with ultraviolet-visible spectroscopy. Moreover, a QuantumDock-optimized graphene-based wearable device is designed that can perform autonomous sweat induction, sampling, and sensing. For the first time, wearable non-invasive phenylalanine monitoring is demonstrated in human subjects toward personalized healthcare applications.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Techniques de biocapteur / Dispositifs électroniques portables / Graphite Type d'étude: Prognostic_studies Aspects: Patient_preference Limites: Humans Langue: En Journal: Adv Mater Sujet du journal: BIOFISICA / QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Techniques de biocapteur / Dispositifs électroniques portables / Graphite Type d'étude: Prognostic_studies Aspects: Patient_preference Limites: Humans Langue: En Journal: Adv Mater Sujet du journal: BIOFISICA / QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique