Discovery of estrogen receptor &#945; targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment.

Xie, Baohua; Xu, Bin; Xin, Lilan; Wei, Yizhou; Guo, Xinyi; Dong, Chune

Discovery of estrogen receptor α targeting caged hypoxia-responsive PROTACs with an inherent bicyclic skeleton for breast cancer treatment.

Xie, Baohua; Xu, Bin; Xin, Lilan; Wei, Yizhou; Guo, Xinyi; Dong, Chune.

Affiliation

Xie B; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Xu B; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Xin L; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Wei Y; Wuhan Britain-China School, Wuhan 430030, China.
Guo X; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Dong C; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, Wuhan University, Wuhan 430071, China. Electronic address: cdong

Bioorg Chem ; 137: 106590, 2023 08.

Article de En | MEDLINE | ID: mdl-37163809

Sujet(s)
Mots clés

Breast cancer; Estrogen receptor α; Hypoxia-responsive; Proteolysis targeting chimera

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Tumeurs du sein Limites: Female / Humans Langue: En Journal: Bioorg Chem Année: 2023 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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