Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification.

Zhao, Xue Zhi; Wang, Wenjie; Lountos, George T; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R

Zhao, Xue Zhi; Wang, Wenjie; Lountos, George T; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R.

Affiliation

Zhao XZ; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Frederick MD USA xuezhi.zhao@nih.gov.
Wang W; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA.
Lountos GT; Basic Science Program, Frederick National Laboratory for Cancer Research Frederick MD USA.
Kiselev E; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA.
Tropea JE; Center for Structural Biology, Center for Cancer Research, National Cancer Institute Frederick MD USA.
Needle D; Center for Structural Biology, Center for Cancer Research, National Cancer Institute Frederick MD USA.
Pommier Y; Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health Bethesda MD USA.
Burke TR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health Frederick MD USA xuezhi.zhao@nih.gov.

RSC Chem Biol ; 4(5): 334-343, 2023 May 10.

Article de En | MEDLINE | ID: mdl-37181631

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Type d'étude: Diagnostic_studies Langue: En Journal: RSC Chem Biol Année: 2023 Type de document: Article Pays de publication: Royaume-Uni

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