Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
Science
; 380(6646): 758-764, 2023 05 19.
Article
de En
| MEDLINE
| ID: mdl-37200435
ABSTRACT
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat-containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. We found that its function was conserved in mammalian cardiomyocytes. This study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Régénération
/
Sarcomères
/
Danio zébré
/
Calcium
/
Myocytes cardiaques
/
Coeur
Limites:
Animals
Langue:
En
Journal:
Science
Année:
2023
Type de document:
Article
Pays d'affiliation:
Pays-Bas