Targeted delivery of alcohol-containing payloads with antibody-drug conjugates.

Grier, Katja E; Hansen, Anders H; Haxvig, Christina S; Li, Xin; Krigslund, Oliver; Behrendt, Niels; Engelholm, Lars H; Rossi, Fabio; Sousa, Bebiana C; Harradence, Grant J; Camper, Nicolas; Qvortrup, Katrine M

Grier, Katja E; Hansen, Anders H; Haxvig, Christina S; Li, Xin; Krigslund, Oliver; Behrendt, Niels; Engelholm, Lars H; Rossi, Fabio; Sousa, Bebiana C; Harradence, Grant J; Camper, Nicolas; Qvortrup, Katrine M.

Affiliation

Grier KE; Department of Chemistry, Technical University of Denmark, Lyngby DK-2800, Denmark. kaqvo@kemi.dtu.dk.
Hansen AH; Department of Chemistry, Technical University of Denmark, Lyngby DK-2800, Denmark. kaqvo@kemi.dtu.dk.
Haxvig CS; Department of Chemistry, Technical University of Denmark, Lyngby DK-2800, Denmark. kaqvo@kemi.dtu.dk.
Li X; Finsen Laboratory, Rigshospitalet/Biotech Research and Innovation Center (BRIC), University of Copenhagen (UCPH), Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark.
Krigslund O; Department of Health Technology, Technical University of Denmark, Lyngby DK-2800, Denmark.
Behrendt N; Department of Health Technology, Technical University of Denmark, Lyngby DK-2800, Denmark.
Engelholm LH; Department of Health Technology, Technical University of Denmark, Lyngby DK-2800, Denmark.
Rossi F; Abzena Ltd, Babraham Research Campus, Babraham, CB22 3AT, UK.
Sousa BC; Abzena Ltd, Babraham Research Campus, Babraham, CB22 3AT, UK.
Harradence GJ; Abzena Ltd, Babraham Research Campus, Babraham, CB22 3AT, UK.
Camper N; Abzena Ltd, Babraham Research Campus, Babraham, CB22 3AT, UK.
Qvortrup KM; Department of Chemistry, Technical University of Denmark, Lyngby DK-2800, Denmark. kaqvo@kemi.dtu.dk.

Chem Commun (Camb) ; 59(47): 7240-7242, 2023 Jun 08.

Article de En | MEDLINE | ID: mdl-37222285

ABSTRACT

ABSTRACT

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Immunoconjugués / Antinéoplasiques Limites: Animals / Humans Langue: En Journal: Chem Commun (Camb) Sujet du journal: QUIMICA Année: 2023 Type de document: Article Pays d'affiliation: Danemark

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