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Single-cell transcriptomics reveal a hyperacute cytokine and immune checkpoint axis after cardiac arrest in patients with poor neurological outcome.
Tamura, Tomoyoshi; Cheng, Changde; Chen, Wenan; Merriam, Louis T; Athar, Humra; Kim, Yaunghyun H; Manandhar, Reshmi; Amir Sheikh, Muhammad Dawood; Pinilla-Vera, Mayra; Varon, Jack; Hou, Peter C; Lawler, Patrick R; Oldham, William M; Seethala, Raghu R; Tesfaigzi, Yohannes; Weissman, Alexandra J; Baron, Rebecca M; Ichinose, Fumito; Berg, Katherine M; Bohula, Erin A; Morrow, David A; Chen, Xiang; Kim, Edy Y.
Affiliation
  • Tamura T; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Cheng C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Chen W; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
  • Merriam LT; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Athar H; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Kim YH; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Manandhar R; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Amir Sheikh MD; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Pinilla-Vera M; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Varon J; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Hou PC; Harvard Medical School, Boston, MA 02115, USA; Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Lawler PR; Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, ON M5G 2N2, Canada; McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
  • Oldham WM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Seethala RR; Harvard Medical School, Boston, MA 02115, USA; Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Tesfaigzi Y; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Weissman AJ; Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Baron RM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Ichinose F; Harvard Medical School, Boston, MA 02115, USA; Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Berg KM; Harvard Medical School, Boston, MA 02115, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
  • Bohula EA; Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Morrow DA; Harvard Medical School, Boston, MA 02115, USA; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: xiang.chen@stjude.org.
  • Kim EY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: ekim11@bwh.harvard.edu.
Med ; 4(7): 432-456.e6, 2023 Jul 14.
Article de En | MEDLINE | ID: mdl-37257452
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cytokines / Transcriptome Limites: Female / Humans Pays/Région comme sujet: America do norte Langue: En Journal: Med Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cytokines / Transcriptome Limites: Female / Humans Pays/Région comme sujet: America do norte Langue: En Journal: Med Année: 2023 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique